Cardiac Troponin

for Earlier Diagnosis of Myocardial Infarctions

Cardiac Troponin
 
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High-Sensitivity Troponin I is the latest addition to Siemens Healthineers’ comprehensive cardiac menu to assist clinicians with the diagnosis and treatment of chest pain patients. Designed to aid in diagnosing acute myocardial infarctions (AMI) through the quantitative measurement of cardiac troponin I in serum or plasma, high-sensitivity troponin plays a critical role in the timely diagnosis of AMI, or heart attacks.

High-sensitivity Troponin I* is now available on the Atellica® IM Analyzer, ADVIA Centaur®Immunoassay System, Dimension® EXL™ and Dimension Vista® Integrated Systems.

  • Offers improved cardiac patient care with a high-sensitivity troponin assay that meets current guideline recommnedations1-3
  • Allows you to measure slight, yet critical, changes between serial troponin I values, giving you confidence in patient results at the low end of the assay range.
  • Delivers reliable results from proven, trusted technology coupled with three new monoclonal antibodies.


Compared to traditional troponin assays, the Siemens Healthineers Atellica IM,  ADVIA Centaur, Dimension EXL and Dimension Vista TNIH assays are able to detect lower levels of troponin and smaller changes to a patient’s troponin levels, which may be an early indication of AMI. This design affords clinicians greater confidence in patient results at the low end of the assay range by delivering precision that provides the ability to measure slight, yet critical, changes between serial troponin I values.

Precision at the low end is important to minimize analytic variation that could confuse a clinician’s assessment of a clinically significant change. With this data in hand, clinicians have the ability to more quickly diagnose and treat patients with suspected AMI, in some cases in as little as one to three hours.

Download the new white paper provides performance data on the ADVIA Centaur High-Sensitivity Troponin I assay 0.3 MB

 


Assay Specifications

Atellica IM High-Sensitivity Troponin I Assay*

Sample TypeSerum, lithium heparin plasma
Sample Volume100 µL
Assay Range2.51 - 25,000.00 pg/mL
Time to First Result10 minutes
On-board Stability31 days
Calibration Interval47 days
LoB0.58 pg/mL
LoD1.27 pg/mL
LoQ2.51 pg/mL

Dimension EXL High-Sensitivity Troponin I Assay*

Sample TypeHuman serum, plasma (lithium heparin)
Sample Volume10 µL
Assay Range4.0 - 25,000.00 pg/mL (ng/L)
Time to First Result10 minutes
ThroughputUp to 200 tests/hour
On-board Stability7 days open well
30 days onboard unpunctured
LoB1.1 pg/mL (ng/L)
LoD2.7 pg/mL (ng/L)
LoQ (20% CV)4.0 pg/mL (ng/L)
LoQ (10% CV)12.0 pg/mL (ng/L)
99th percentile (n = 2010)Combined: 60.4 pg/mL (ng/L)
Male: 76.2 pg/mL (ng/L)
Female: 51.4 pg/mL (ng/L)

99th percentile value determined using combined gender data and lithium heparin sample type.

Dimension Vista High-Sensitivity Troponin I Assay*

Sample TypeHuman serum, plasma (lithium heparin)
Sample Volume10 µL
Assay Range3.0 - 25,000.00 pg/mL (ng/L)
Time to First Result10 minutes
ThroughputUp to 200 tests/hour
On-board Stability7 days open well
30 days onboard unpunctured
LoB1.0 pg/mL (ng/L)
LoD2.0 pg/mL (ng/L)
LoQ (20% CV)3.0 pg/mL (ng/L)
LoQ (10% CV)10.0 pg/mL (ng/L)
99th percentile (n = 2010)Combined: 58.9 pg/mL (ng/L)
Male: 78.5 pg/mL (ng/L)
Female: 53.7 pg/mL (ng/L)

99th percentile value determined using combined gender data and lithium heparin sample type.

ADVIA Centaur High-Sensitivity Troponin I Assay*

Sample TypeHuman serum, plasma (lithium heparin)
Sample Volume100 µL
Assay Range2.50 – 25,000.00 pg/mL (ng/L)
Time to First ResultXP/XPT: 18 minutes
ThroughputUp to 240 tests/hour
On-board Stability28 days
Calibration Interval14 days
LoB0.90 pg/mL (ng/L)
LoD2.21 pg/mL (ng/L)
LoQ (20% CV)2.50 pg/mL (ng/L)
LoQ (10% CV)4.50 pg/mL (ng/L)
99th Percentile47.34 ng/L (pg/mL)

 



Cardiac Menu

 ADVIA Centaur® SystemsAtellica® SolutionDimension® EXL™ Systems

Dimension Vista® Systems

IMMULITE® SystemsStratus® CS Systems
BNP     √     √        √  
CKMB Mass     √     √       √      √      √      √
CKMB Isoenzyme         √      √  
D-Dimer            √      √
Galectin-3     √*      
High-Sensitivity CRP         √      √      √      √
High-Sensitivity Troponin I1
     √     √       √      √   
Myoglobin     √     √        √      √      √      √
NT-proBNP     √     √       √      √       √
Tnl-Ultra™     √ǂ     √       
Troponin I          √ǂ      √ǂ      √      √ǂ

*Under development. Not commercially available. Future availability cannot be guaranteed.
Not available for sale in the U.S. 
ǂGuideline-acceptable
1. Available on the ADVIA Centaur XP and XPT Systems only

The products featured here may not be commercially available in all countries. Due to regulatory restrictions, their future availability cannot be guaranteed. Please contact your local Siemens Healthineers representative for further details.



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* High-sensitivity troponin I is not currently available for sale in the U.S.

The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens organization for further details.